Wallingford are forced into four changes as they bid to make it six South West 1 East wins a row at home to mid-table Buckingham on Saturday.
Hooker Tom Hill, lock Dorian Jenkins, scrum half Derek Viljoen and utility back Angus Brettell are unavailable.
Ed Jenkins, Pat McKenna, Matt Dawes and Ralph Smith come in.
Head coach Chris Norrington said: “We want to finish the year on a good note with another home win. If we stick together, we’ll be fine.”
Former captain Jez Hicks returns to the Witney squad after injury as the Southern Counties North leaders host Milton Keynes.
Ali McRoberts is added to the back line.
Wallingford (v Buckingham, home): Venners, Smith, Collett, Holton, R Turner, Sayce, Dawes, Blaszko, Small, E Jenkins, Rowberry, McKenna, Chapman, W Woodward, Jeffreys (capt). Reps: Simons, Windsor, Marris.
Witney (v Milton Keynes, home): from Mitchem, L Collins, McRoberts, Strutt, J Lamb (capt), Monks, H Lamb, G Campbell, Serle, S Collins, Kerr, Richens, Fowler, Rowles, Bennett, J Hicks, Muller, Caffekey.
Witney 2nd (Maidenhead 3rd, home): from D Godfrey, Burke, Brocklebank, G Williams, S Copperwheat, Perry, Chatterton (capt), Hare, MacBurnie, Davies, Austin, Douglas, G Bibby, Phillips, Murray, Mills, Taafe, Gurney, Harper.
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