George Kruis has been ruled out of England’s last two autumn matches because of a calf injury sustained against New Zealand on Saturday.
Kruis was replaced by Charlie Ewels in the 66th minute of the 16-15 defeat at Twickenham and will not play any part in the remaining Quilter Internationals against Japan and Australia.
It is a bitter blow to the Saracens second row who has impressed so far this autumn, not least for his expertise as line-out caller.
Maro Itoje, Ewels, Elliott Stooke and Courtney Lawes are the locks included in a 30-man squad that is to assemble at England’s Surrey training base on Tuesday afternoon to begin preparations for the visit of Japan.
Full-back Mike Brown is overlooked once more and there are minor doubts over Dylan Hartley and Manu Tuilagi, who are nursing thumb and groin issues.
Eddie Jones names his team to face the side he coached at the 2015 World Cup on Thursday.
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