The A4074 near Woodcote has been closed in both directions after a crash involving for cars.
One woman driver and five men have been taken to hospital for treatment but police said the injuries were not life threatening.
The accident, close to The Oratory School, happened shortly before 6.40am this morning and involved a grey peugeot saloon car, a grey BMW 320, a Black Saab 93 and a black Mazda MX-5.
The road is closed between the Checkendon turn and the B4526.
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