Staff members from John Radcliffe Hospital are set to take on a 58km endurance challenge to support the hospital's neuroscience unit.
Team 'Wait For Me Willis', includes Kumi, Cat, Natalie, Tash and Isla who are all part of the neuroscience and intensive care units at the hospital.
They range from experienced long-distance runners to novices who are eager to take on the challenge.
They will take on the Jurassic Coast Ultra Challenge, a gruelling test covering a distance of 58km, including 1,700m of ascent.
The group shares a goal of not just crossing the finish line with "a bit of dignity", but also to raise funds for the Oxford Hospitals Charity, specifically the neuroscience unit.
Team captain, Kumi Okamura, who has previously raised funds for Oxford Hospitals Charity through the London Marathon and Oxford Half Marathon, has gathered her colleagues for the challenge.
In preparation, the team has trained in a range of locations, with Ms Okamura travelling to Tokyo to compete in the marathon there.
Meanwhile, Cat Lamb took part in a 26.2 mile trail marathon known as the ‘Exmoor Goat’.
Other members trained in places including Arthur’s Seat in Edinburgh and the Dorset Hills.
Novice runner Natalie Thrale said: "When Kumi dragged me into this 'fun challenge' I hadn't run more than 5km.
"My natural habitat is the squash court, swimming pool or vegetable patch, not miles of trails.
"However, I can't resist the opportunity to get a new rucksack, so I said yes... we will see how that turns out."
Ms Lamb explained the team name, saying: "As myself and Natalie work within neurovascular service we wanted something to incorporate that into the name.
"There is a well-known junction of several important arteries at the bottom part of the brain called the ‘circle of willis’.
"The ‘wait for me’ part is us all shouting ‘wait for me’, hence Wait for me Willis became the team name."
The neuroscience unit at John Radcliffe Hospital provides care for patients with serious neurological conditions and injuries.
The funds raised will help buy additional equipment to improve patients’ comfort and well-being during their stay.
Ms Okamura said the aim was to make "patients' lives a little less challenging and a little more comfortable while they are with us".
The group will start their journey at Corfe Castle in Dorset on Saturday morning, passing through Swanage, Lulworth Cove, and Durdle Door, before progressing to the Weymouth finish line.
To support the group, donations can be made via their JustGiving page.
The team has already raised £2,277, flying past their target of £1,000.
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