A 67-year-old man from Bicester has died following a crash on the A41 at Bicester.
A green Skoda Superb and a red Scania P360 lorry collided on the road at 8am.
A 67-year-old man from Bicester, who was the driver of the Skoda, was treated by paramedics but died at the scene.
His next of kin have been informed.
The driver of the lorry was not injured.
Investigating officer, PC Neil Bowker of the Joint Operations Roads Police Unit based at Bicester, said: "We are appealing for information to help us in our investigation following this road traffic collision.
"If anyone has witnessed it or has dash cam footage of the incident we would ask them to get in touch."
If you have any information relating to this case, please call 101 quoting reference '43180087464', or contact Crimestoppers anonymously.
Comments: Our rules
We want our comments to be a lively and valuable part of our community - a place where readers can debate and engage with the most important local issues. The ability to comment on our stories is a privilege, not a right, however, and that privilege may be withdrawn if it is abused or misused.
Please report any comments that break our rules.
Read the rules here