Mason Churton scored the only goal as North Berks League Division 4 side Hagbourne United knocked Division 2 Faringdon Town Res out with a shock 1-0 second-round home win.
Division 4 Kennington Athletic enjoyed a surprise 3-2 win at home to Division 2 Saxton Rovers Res. James Foster netted twice for the visitors, but goals from Rob Andrews, Andy Dier and Matty Hutton won it for the underdogs.
Division 3 Hanney United lost 3-1 on penalties to Division 4 league leaders Turnpike Sports after the sides were locked at 5-5 after 120 minutes.
Matt Woodside hit a hat-trick for Hanney alongside Neil Pimm and James Bishop, but Turnpike matched them with doubles from Mark Davies and Steve James and an Ian Rollinson strike.
Division 5 Wallingford Town Res beat Reading League Theale 2-0 on penalties after the sides were level at 5-5 following extra-time.
Carl Fisher (2), Jack Eccles, Aaron Fell and Steve Wood, with a penalty, scored for Wallingford in normal time.
Division 4 Warborough United lost 4-2 at home to Mortimer Res from Division 1 of the Reading League with Kearan Russell and Darryl Potter doing the damage.
Chris Stringer (2) and Wes Coster scored the goals that gave Division 2 Marcham a 3-1 win at Ardington & Lockinge Res from Division 4.
The same divisional match-up saw Wantage Town A triumph 2-1 at home to Grove Rangers with Ben Eltham and Liam McCullough on target.
Joe Ledbury replied for the visitors.
Division 5 Uffington United lost 5-4 to Division 2 Radley. Mark Jones scored twice alongside George Heath and Louis Butler, but it was not enough as Rich Hathaway, with two, and goals from Frankie Merola, Karl Guschtscha and Mike Steers won the match for Radley.
Sutton Courtenay hammered Challow 6-1 thanks to a John Gilseman four-timer and a Dan Page double. Challow netted via Nick Gordon.
Leigh Andrews bagged a brace and James Head and Shane Blake netted as Coleshill United defeated East Hendred 4-3.
Hendred replied through a Marc Reid double and a Dan Sayer strike.