A strike from Jamie Kennedy secured a 1-0 victory for Ducklington against lowly Aston.
The victory keeps Ducklington two points clear at the top of the Premier table.
Minster Lovell went down 4-1 to West Witney, who moved into second place.
A brace each from Karl Dodds and Kevin Lewis settled it with Nathan Harris getting a goal back.
Charlbury moved level on points with their opponents, Chipping Norton, after they picked up a 3-2 win over the visitors. Shaun Gilbert (2) and Jacob Hancock scored the goals.
Witney Royals went down 2-1 to Carterton Town A. Chris Coggins was on target for the hosts, but goals from Lee Moseley and Chris MacNeil won it.
Sean King scored the only goal as Hailey beat Hanborough 1-0.
Hailey Res remain five points clear at the top of Division 1 after a 4-0 triumph over Kingham.
Kristian Collis, Mo Semlali, Darryl Kew and John Andrews all netted. Bourton Rovers suffered their first defeat of the season as they were beaten 2-1 by Brize Norton. Pavel Brink got both for the visitors with a Richard Taylor own goal Bourton’s response.
FC Nomads were on the wrong end of a 5-1 thumping by Carterton Pumas. Dave Hurp scored for the hosts but goals from Dan Wilkinshaw (2), Kai Merrit, Shaun Dunlop and Ashley Davies clinched it.
Eynsham SSC emerged victorious 2-1 in their local derby against Freeland. Chris Greenaway scored for Freeland, but a brace from John Ayres earned the points for Eynsham.
North Leigh A beat Spartan Rangers 2-1. Justin Timms and Craig Greenhalgh scored for the hosts, with Matt Townsend getting one back.
FC Hollybush led 5-1 against AC Finstock before the Division 2 game was abandoned due to an injury to Finstock keeper, Matty Claridge.
The stricken stopper was taken to the John Radcliffe Hospital with a suspected fractured ankle.
Earlier, Karim Diallo (2), Dave Cooper (2) and Paul Dray had put Hollybush clear with Ashley Overton pulling one back for Finstock.
FC Mills earned their second three points of the season with a 2-0 win over Witney Royals Res. Matt Parr and Rob DeBanks netted. Milton also picked up the points via a 4-2 win over Bampton. Rob James (2), Dan Hooton and Leigh Hillary were on target for Milton with Adam Lee and Aaron Robbins hitting back for Bampton.
Witney Wanderers stunned Carterton Rangers 7-1. Marcelo Guitherme scored a hat-trick adding to goals from Stu Morrison (2), Bernie Crumlish and Jamie Jackson. Ben Pearce replied.
Bampton Utd inflicted Middle Barton’s first defeat of the season in Division 3 by 7-1. Conor Kelley grabbed a treble, with Connor O’Shea and Liam Ward getting braces. Lee Hays scored Middle Barton’s consolation. Brize Norton Res lost a nine goal thriller with Minster Lovell Res 5-4.
Rob Brown (2), Lee Williams and Nigel Byng scored for the hosts, but Minster won it through David Souch, Nathan Bowles, Stuart Mitchell, Arron Mullis and Craig Sallis.
Carterton Town B thumped Charlbury Town Res 5-1. Dan Sollis banged in a hat-trick with Mark Hawkins adding two. Chipping Norton Res went down 3-2 to Wootton. John Dunn scored both for the hosts but Mitch Larman (2) and Dave Oliver gave Wootton the honours.
Div 4 Tower Hill showed off their impressive title credentials after a 6-1 mauling of promotion hopefuls Eynsham SSC Res. Jamie Goodwin and Gary Smith each scored two with Joe Brown and George French getting the others.
Corinthians and Aston Res had to settle for a point apiece from their 3-3 draw. Frank Webb scored all three for the hosts but goals from Matt Gardener and Ben Waldron (2) brought parity to the score line.
Two first half goals for FC Hollybush Res were enough to take all three points at Chadlington Res in a 2-0 win.
Joe Hatt and Dean Spivey were on target for Hollybush.
Jack Busby cup Joel Spalding scored a hat-trick in Spartan Rangers Res 6-0 trouncing of Bourton Res. Neil Jackson and Ben Allen got the others with goalkeeper Steve Thomas also hitting the target.
Ducklington Res narrowly edged through 2-1 against Kingham.
Matt Swift scored for the visitors, but goals from Josh Hartley and Aidan Ford settled the tie.
Wootton Res put their poor league form behind them as they eased through to the next round after a convincing 4-0 success over Milton Res. Jacob Cook (2), Ryan Royal and Martin Brion all scored.