A coach carrying children and a car have been involved in a crash between the A4074 and the B4015 Oxford Road in Burcot near Abingdon.
The A415 is now closed both ways due to the serious incident.
Thames Valley Police said the coach was carrying children but they were not hurt in the crash at about 4.45pm.
However, a woman has been trapped in her vehicle.
A South Central Ambulance spokeswoman said the woman was taken to the John Radcliffe Hospital for treatment.
The driver of the coach was also treated at the hospital.
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It is not yet known if the woman was seriously injured.
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