A three-car crash on the A40 at Eynsham is currently causing long delays for rush-hour drivers.
The eastbound carriageway is currently closed between the Eynsham roundabout and Wolvercote roundabout following the accident at 3.40pm.
One of the drivers is being treated at the scene, although his injuries are not thought to be life-threatening.
Light vehicles are being diverted through Bladon but lorries are being kept at the scene, near the Cassington traffic lights.
Thames Valley Police spokesman Marianne Stockton said it is not known when the carriageway will re-open.
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