THE A34 was partially blocked near Wendlebury after a car overturned.
Oxfordshire County Council said it caused the northbound carriageway to be blocked but that one lane was now open.
Another crash also took place involving two cars and a lorry at about 12.50pm, but the county council said this was cleared by about 1pm.
Stagecoach Oxfordshire said to expect "major delays" on its bus services.
Thames Valley Police said no one involved was seriously injured but that the road closure remained in place for the cleanup of a fuel spillage.
Traffic in the area is now easing after the accident was cleared at about 3.30pm.
S5 SERVICE UPDATE: RTC reported on the northbound A34 at Wendlebury. Expect major delays.
— Stagecoach Oxford (@Stagecoach_Ox) October 28, 2015
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